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Can I build any custom PC and I have it run Linux ?
What if I need to have Adobe Pro and MS Word full versions for work ?
In regard to any custom PC, absolutely Linux runs on most hardware.
Adobe, and word aren’t written native to Linux, there are solutions such as wine that can help, or you can dual boot or use a virtual machine
I would build it with AMD or Intel components only personally, because Nvidia still relies on a closed-source driver.
Adobe and Word will not work on Linux.