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To be less hypothetical and more scary: Think about all the ancient pathogens that are dormant in the permafrost. Those could become a real problem when it starts to thaw because of global warming.
There was already an outbreak of thousand year old Anthrax from thawed animal corpses in Siberia several years ago.
Or any smallpox samples sitting in the back of an old lab, like the ones they found in 2014. Or the smallpox samples that the US and Russian governments keep
as WMDsfor research purposes.The TV show Fortitude has a similar plotline. Would recommend!