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Feels like something from Malazaan - ancient dragon getting blown tf up with an explosive bomb comes to mind…
There is a comic that I can’t remember the title of right now. But the plot is basically the whole country of Japan gets Isekai’d, land and all
Summoning Japan / Nihonkoku Shoukan
Where they kill an Oni with a 35mm autocannon
Yes, that’s it! Now that you mentioned it I’ve started to re read it. It was as wack as I remember lol. And it was an ogre btw!