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I don’t think so, the premise is that water can be converted to wine. Water here does not mean the chemical composition (ie h2o) but rather as a concept. So once water is converted the whole of it is refered to as “wine”. If you were to separate it into components you can do so but they won’t be called wine. Then you can use jesus to convert the water component again and repeat the process.
Another caveat, water is more than just h2o ie, what we usually refer to as “water” can contain many things like minerals, salt and even bacteria etc, in fact i doubt you can get pure h2o easily.
I have a cheap knock off jesus from Alibaba and even he can turn wine into winier wine, if you tell him that it’s just red water. Maybe you are using your jesus wrong?