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Loss?
Here’s the comic on the left (titled “Loss”) and its shorthand on the right that people sneak into everything to reference it.
The webcomic (called “CTRL-ALT-DEL”) was mostly comedy, but then pivoted out of the blue with this dark, dramatic, wordless strip. The whiplash in tone led to a lot of jokes and people trying to meme it and slip references to it into everything.
Oh wow, I used to read this comic like 15 years ago.