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I’ve been single boot on Fedora for a little over a year. The biggest issue for gaming that I’ve seen are because of anti-cheats that don’t support Linux.
You always need to mention that even that’s very uncommon. Most AC doesn’t have an issue. Kernel-level ones usually do (and I’d stay away from them anyway), as well as some Chinese ones. Maybe a few others. 99.9% of the time it’s fine though.
It’s gotten to the point I don’t even check Protondb anymore before buying a game.
I had issues with setting up Fefora on NVIDIA for gaming (skill issue, probably), but switching to Nobara has fixed all of them and I’ve been single boot for almost a year since then.