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Maybe you have not changed the documents/etc directory paths, OneDrive breaking games is completely new for me.
There’s a few games I play that have a launcher that lets you load mods before the actual game launches. The attempts to sync stuff in the doc folders runs into file locks while it doing stuff in that folder.
I had it working without one drive. Then something updated and I had to go into the registry to get it working again.
Maybe it’s because you touched the registry? You can rigut click the docs folder, properties, location, move, pick the new one, done. Forever. For me at least.
The registry is what fixed it.