Unfortunately this is one of the cases where you’re going to have to do some research.

Check ProtonDB to see how a game plays on Linux. I’m assuming the flight simulator would be problematic.

Usually the periferal drivers are built into the Linux kernel. Your keyboard and mice will just work, gamepads as well. Niche stuff like wheels and flight controllers will likely not work out of the box and you’ll have to find a community based software to support it. Sucks.

If I were you I’d boot a virtual machine or a live USB drive and try it out. If you’re not comfortable with the amount of compatibility just don’t install it. Nothing lost