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The solution is a desk pad. If 100% of the desk is a mouse pad you are never in the wrong spot.
Doesn’t really address my point. If your keyboard forces your hand too far off the side… Even if your mouse has a ton of mat space over there, you still have to reach way over there.
I have my mouse in between my two keyboard halves. Off to the side if I’m gaming, and using only one half of the keyboard, the other half unplugged, or just moved up and out of the way.