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If you got the one where everyone dies, yeah you should probably replay it and at least have a short list of the specific scenes/choices that determine the “best” ending(it’s something like 5).
There are also some “hidden” endings to quest chains, where the best outcome is only available if you do a seemingly unrelated quest first or make certain choices early in the chain. So if you’re interested in getting all the best outcomes, a full guide is needed.
Note that some of the "hidden chain outcomes might be bugs, so at least one isn’t always listed in all guides:
!!Spoiler!! - Spoils ending to an early main quest chain.
If you free the whispering hillock spirit before talking to the village leader, it prevents Anna from turning later and the game acts as if the kids are safe(although they don’t show up where they otherwise would).