I use pipewire with Ardour and Neural DSP VSTs (over wine) with zero issues on EndeavourOS. I really hadn’t expected that. Now, I generally just use this stuff to not have to buy many physical pedals so I rarely do recording, but that has worked as well.

You seem to be way more advanced than me in that regard, so I can’t say if it would work for you, but it was so much easier and better than when I tried the same thing years ago. I’d suspect that GuitarRig works as well, though I haven’t tried. I may just do so this weekend, but can’t promise.

I have GuitarPro running with wine as well.