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If 99℅ of pregnancies are screened and the gene’s edited then, yeah, you’re effectively eliminating people with Down’s from our world.
Unless society collapses and the Quirk returns naturally.
Realistically, gene editing will never be affordable for the vast majority of the world’s population. But today, abortion is chosen up to 93% of the time instead. If the alternative is a live, healthy birth, I can’t see any ethical issues.
https://obgyn.onlinelibrary.wiley.com/doi/10.1002/pd.2910