SponserBlock provides defenses against that with minor modifications.

It’s been suggested that that would be an absolute last ditch effort because it trashes your ability to display targeted ads or update them without absolutely wrecking your CDNs. You also can’t have the ad link to anything because that would allow the client to trivially detect and skip it.

Ad Nauseam also provides the nuclear option of downloading the ads, pretending to display them, and even pretending to click them. You might still have to wait out the delay for while the ad should be playing for the first ad, but once you get past that they can’t prevent the player skipping ads without also preventing you skipping 30s of boring content.