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I don’t think isolating ourselves from the only people that we can trade with without crossing an ocean is feasible, but we should certainly give nothing voluntarily.
I don’t think proximity is a good enough excuse to do business with a hostile nation, especially in a world of technology that makes things like inter continental trade much easier. We have ports on both sides of our country, and negotiated trade deals, to reach these markets with further negotiations taking place as we speak.
Will it hurt? Yes.
Is that a reason to not disconnect from the USA? No.